Independent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study

Abstract Background There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) also hardly regarding sitting time (ST). The purpose of this study was examine independent interactive association PA ST with HUA. Methods A cross-sectional analysis performed 38,855 participants (aged 18–79) enrolled from Henan Rural Cohort Study at baseline (2015 2017). levels were assessed by using International Physical Activity Questionnaire (IPAQ). HUA defined as a serum uric acid level > 7.0 mg/dL for males 6.0 females. Multivariable logistic regression linear models applied between or level. Interaction plots used visualize interaction effects Results inversely related ( β − 0.15, 95% confidence interval CI ) 0.22, 0.07), but positively 2.12, 1.90, 2.34). Metabolic equivalent (MET-hour/day) associated decreased prevalence (odds ratio OR 0.97, 0.96, 0.99), while per hour increased (OR 1.05, 1.04, 1.06). significant P < 0.001). Conclusion Exposure higher independently HUA, prevalence. Meanwhile, daily might attenuate protective effect Trial registration has been registered Chinese Clinical Register (Registration number: ChiCTR-OOC-15006699 ).